Scott Ferguson

About

I am a microbiologist and my research focuses on applying modern biomedical research techniques to develop new antimicrobial solutions for the primary agricultural industry and the biomedical industry. I specialise in investigating the mechanism of action of novel antimicrobials on large multidisciplinary translational projects. I collaborate with a wide range of scientists (e.g., biologists and medicinal chemists) as well as veterinarians, agribusiness consultants, and end users to investigate the biological activity of newly synthesised compounds, mainly to solve challenges focused on overcoming antimicrobial resistance. I also collaborate with a wide range of NZ and international researchers to develop; new nitrification inhibitors, sanitisers to prevent bovine mastitis, therapeutics (antimicrobials) to treat bovine mastitis and bacterial infections in companion animals, and therapeutics to overcome human antimicrobial resistance.

Work

University of Otago

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Senior Research Fellow

New Zealand

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Education

University of Otago

New Zealand
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PhD

Publications

Comparison of an on-farm point-of-care diagnostic with conventional culture in analysing bovine mastitis samples

Journal of Dairy Research

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Comparative genomics of endemic Staphylococcus aureus ST1 in New Zealand

mSphere

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Allenamides as a Powerful Tool to Incorporate Diversity: Thia‐Michael Lipidation of Semisynthetic Peptides and Access to β‐Keto Amides

Angewandte Chemie International Edition

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Allenamides as a Powerful Tool to Incorporate Diversity: Thia‐Michael Lipidation of Semisynthetic Peptides and Access to β‐Keto Amides

Angewandte Chemie

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Synthesis, Structure–Activity Relationship Study, Bioactivity, and Nephrotoxicity Evaluation of the Proposed Structure of the Cyclic Lipodepsipeptide Brevicidine B

Journal of Natural Products

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Synthesis, Antibacterial Activity, and Nephrotoxicity of Polymyxin B Analogues Modified at Leu-7, d-Phe-6, and the N-Terminus Enabled by S-Lipidation

ACS Infectious Diseases

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Comammox Nitrospira Clade B is the most abundant complete ammonia oxidizer in a dairy pasture soil and inhibited by dicyandiamide and high ammonium concentrations

Frontiers in Microbiology

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Stereochemical Effects on the Antimicrobial Properties of Tetrasubstituted 2,5-Diketopiperazines

ACS Medicinal Chemistry Letters

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A Concise Synthetic Strategy Towards the Novel Calcium-dependent Lipopeptide Antibiotic, Malacidin A and Analogues

Frontiers in Chemistry

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Disruption of Metallostasis in the Anaerobic Human Pathogen Fusobacterium nucleatum by the Zinc Ionophore PBT2.

ACS infectious diseases

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Multiple Bactericidal Mechanisms of the Zinc Ionophore PBT2

mSphere

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Synthesis of paenipeptin C′ analogues employing solution-phase CLipPA chemistry

Organic & Biomolecular Chemistry

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Synthesis and Biological Evaluation of (-) and (+)-Spiroleucettadine and Analogues.

ChemMedChem

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C-2 derivatized 8-sulfonamidoquinolines as antibacterial compounds.

Bioorganic & medicinal chemistry

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“CLipP”ing on lipids to generate antibacterial lipopeptides

Chemical Science

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Substituted sulfonamide bioisosteres of 8-hydroxyquinoline as zinc-dependent antibacterial compounds.

Bioorganic & medicinal chemistry letters

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Structure of F1-ATPase from the obligate anaerobeFusobacterium nucleatum

Open Biology

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The Synthesis of (±)-Oxyisocyclointegrin

European Journal of Organic Chemistry

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Bifidobacterium bifidum ATCC 15696 and Bifidobacterium breve 24b metabolic interaction based on 2'-O-fucosyl-lactose studied in steady-state cultures in a Freter-style chemostat.

Applied and Environmental Microbiology

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Microtiter Screening Reveals Oxygen-Dependent Antimicrobial Activity of Natural Products Against Mastitis-Causing Bacteria

Frontiers in Microbiology

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Chemical Synergy between Ionophore PBT2 and Zinc Reverses Antibiotic Resistance

mBio

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Complete Genome Sequence of a New Zealand Isolate of the Bovine Pathogen Streptococcus uberis.

Genome announcements

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Regulation of the thermoalkaliphilic F1-ATPase from Caldalkalibacillus thermarum.

Proceedings of the National Academy of Sciences of the United States of America

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A1Ao-ATP synthase of Methanobrevibacter ruminantium couples sodium ions for ATP synthesis under physiological conditions.

The Journal of biological chemistry

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Structural investigations of the membrane-embedded rotor ring of the F-ATPase from Clostridium paradoxum.

Journal of bacteriology

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Biochemical and molecular characterization of a Na+-translocating F1Fo-ATPase from the thermoalkaliphilic bacterium Clostridium paradoxum.

Journal of bacteriology

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